HAAO

GENE INFORMATION

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Gene name

HAAO

Synonyms

Description

3-hydroxyanthranilate 3,4-dioxygenase (HGNC Symbol)

Entrez gene summary

3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p21

Chromosome location (bp)

42767089 - 42792593

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162882 (version 78.38)

Entrez gene

23498

UniProt

P46952 (UniProt - Evidence at protein level)

neXtProt

NX_P46952

Antibodypedia

HAAO antibodies
 

PROTEIN VIEW

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HAAO-001
 
HAAO-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HAAO-001 ENSP00000294973
ENST00000294973
P46952
Show all »
Show » Show » 286 32.6 No 0
HAAO-004 ENSP00000412601
ENST00000431905
C9IY88
Show all »
Show » Show » 177 20.5 No 0