ERCC3

GENE INFORMATION

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Gene name

ERCC3 (HGNC Symbol)

Synonyms

BTF2, GTF2H, RAD25, TFIIH, XPB

Description

Excision repair cross-complementation group 3 (HGNC Symbol)

Entrez gene summary

This gene encodes an ATP-dependent DNA helicase that functions in nucleotide excision repair. The encoded protein is a subunit of basal transcription factor 2 (TFIIH) and, therefore, also functions in class II transcription. Mutations in this gene are associated with Xeroderma pigmentosum B, Cockayne's syndrome, and trichothiodystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Chromosome

2

Cytoband

q14.3

Chromosome location (bp)

127257290 - 127294176

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163161 (version 78.38)

Entrez gene

2071

UniProt

P19447 (UniProt - Evidence at protein level)

neXtProt

NX_P19447

Antibodypedia

ERCC3 antibodies
 

PROTEIN VIEW

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ERCC3-001
 
ERCC3-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ERCC3-001 ENSP00000285398
ENST00000285398
P19447
Show all »
Show » Show » 782 89.3 No 0
ERCC3-011 ENSP00000408901
ENST00000456257
Show » 188 21.4 No 0