CLDN1

GENE INFORMATION

? »

Gene name

CLDN1 (HGNC Symbol)

Synonyms

ILVASC, SEMP1

Description

Claudin 1 (HGNC Symbol)

Entrez gene summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q28

Chromosome location (bp)

190305701 - 190322475

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163347 (version 78.38)

Entrez gene

9076

UniProt

O95832 (UniProt - Evidence at protein level)

neXtProt

NX_O95832

Antibodypedia

CLDN1 antibodies
 

PROTEIN VIEW

? »
 
 
 
CLDN1-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLDN1-001 ENSP00000295522
ENST00000295522
O95832
Show all »
Show » Show » 211 22.7 No 3