EOMES

GENE INFORMATION

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Gene name

EOMES (HGNC Symbol)

Synonyms

TBR2

Description

Eomesodermin (HGNC Symbol)

Entrez gene summary

This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Chromosome

3

Cytoband

p24.1

Chromosome location (bp)

27715949 - 27722711

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163508 (version 78.38)

Entrez gene

8320

UniProt

O95936 (UniProt - Evidence at protein level)

neXtProt

NX_O95936

Antibodypedia

EOMES antibodies
 

PROTEIN VIEW

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EOMES-001
 
EOMES-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EOMES-001 ENSP00000295743
ENST00000295743
O95936
Show all »
Show » Show » 686 72.7 No 0
EOMES-002 ENSP00000388620
ENST00000449599
O95936
Show all »
Show » Show » 705 74.9 No 0