PYHIN1

GENE INFORMATION

? »

Gene name

PYHIN1 (HGNC Symbol)

Synonyms

IFIX, MGC23885

Description

Pyrin and HIN domain family, member 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Chromosome

1

Cytoband

q23.1

Chromosome location (bp)

158930796 - 158977054

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163564 (version 78.38)

Entrez gene

149628

UniProt

Q6K0P9 (UniProt - Evidence at protein level)

neXtProt

NX_Q6K0P9

Antibodypedia

PYHIN1 antibodies
 

PROTEIN VIEW

? »
 
 
 
PYHIN1-001
 
PYHIN1-002
 
PYHIN1-003
 
PYHIN1-004
 
PYHIN1-005
 
PYHIN1-006
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PYHIN1-001 ENSP00000357122
ENST00000368140
Q6K0P9
Show all »
Show » Show » 492 55.1 No 0
PYHIN1-002 ENSP00000357120
ENST00000368138
Q6K0P9
Show all »
Show » Show » 483 54.1 No 0
PYHIN1-003 ENSP00000376083
ENST00000392254
Q6K0P9
Show all »
Show » Show » 461 51.9 No 0
PYHIN1-004 ENSP00000376082
ENST00000392252
Q6K0P9
Show all »
Show » Show » 452 51 No 0
PYHIN1-005 ENSP00000357117
ENST00000368135
Q6K0P9
Show all »
Show » Show » 245 27 No 0
PYHIN1-006 ENSP00000407616
ENST00000458222
X6RHR0
Show all »
Show » 150 16.9 No 0