CTLA4

GENE INFORMATION

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Gene name

CTLA4 (HGNC Symbol)

Synonyms

CD, CD152, CD28, CELIAC3, GSE, ICOS, IDDM12

Description

Cytotoxic T-lymphocyte-associated protein 4 (HGNC Symbol)

Entrez gene summary

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q33.2

Chromosome location (bp)

203867786 - 203873960

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163599 (version 78.38)

Entrez gene

1493

UniProt

P16410 (UniProt - Evidence at protein level)

neXtProt

NX_P16410

Antibodypedia

CTLA4 antibodies
 

PROTEIN VIEW

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CTLA4-001
 
CTLA4-002
 
CTLA4-004
 
CTLA4-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTLA4-001 ENSP00000303939
ENST00000302823
P16410
Show all »
Show » Show » 223 24.7 Yes 1
CTLA4-002 ENSP00000409707
ENST00000427473
P16410
Show all »
Show » Show » 137 14.9 No 0
CTLA4-004 ENSP00000417779
ENST00000472206
P16410
Show all »
Show » Show » 79 8.9 Yes 0
CTLA4-005 ENSP00000295854
ENST00000295854
P16410
Show all »
Show » Show » 174 19.1 Yes 0