IL17RC

GENE INFORMATION

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Gene name

IL17RC (HGNC Symbol)

Synonyms

IL17-RL

Description

Interleukin 17 receptor C (HGNC Symbol)

Entrez gene summary

This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]

Chromosome

3

Cytoband

p25.3

Chromosome location (bp)

9917074 - 9933630

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163702 (version 78.38)

Entrez gene

84818

UniProt

Q8NAC3 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NAC3

Antibodypedia

IL17RC antibodies
 

PROTEIN VIEW

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IL17RC-001
 
IL17RC-010
 
IL17RC-011
 
IL17RC-014
 
IL17RC-019
 
IL17RC-020
 
IL17RC-022
 
IL17RC-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL17RC-001 ENSP00000295981
ENST00000295981
Q8NAC3
Show all »
Show » Show » 791 86.2 Yes 1
IL17RC-010 ENSP00000414609
ENST00000438091
C9JSZ3
Show all »
Show » 330 36.6 Yes 0
IL17RC-011 ENSP00000401128
ENST00000436503
C9K0M1
Show all »
Show » 416 46.1 Yes 0
IL17RC-014 ENSP00000373323
ENST00000383812
Q8NAC3
Show all »
Show » Show » 705 76.9 Yes 1
IL17RC-019 ENSP00000384969
ENST00000403601
Q8NAC3
Show all »
Show » Show » 720 78.7 Yes 1
IL17RC-020 ENSP00000396064
ENST00000413608
Q8NAC3
Show all »
Show » Show » 707 77.2 Yes 1
IL17RC-022 ENSP00000407894
ENST00000455057
Q8NAC3
Show all »
Show » Show » 688 75 Yes 1
IL17RC-201 ENSP00000395315
ENST00000416074
Show » 690 75.3 Yes 1