ERAP1

GENE INFORMATION

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Gene name

ERAP1 (HGNC Symbol)

Synonyms

A-LAP, ARTS-1, ERAAP1, KIAA0525, PILS-AP

Description

Endoplasmic reticulum aminopeptidase 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Chromosome

5

Cytoband

q15

Chromosome location (bp)

96760810 - 96808100

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164307 (version 78.38)

Entrez gene

51752

UniProt

Q9NZ08 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NZ08

Antibodypedia

ERAP1 antibodies
 

PROTEIN VIEW

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ERAP1-001
 
ERAP1-002
 
ERAP1-003
 
ERAP1-004
 
ERAP1-005
 
ERAP1-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ERAP1-001 ENSP00000296754
ENST00000296754
Q9NZ08
Show all »
Show » Show » 948 107.8 Yes 0
ERAP1-002 ENSP00000406304
ENST00000443439
Q9NZ08
Show all »
Show » Show » 941 107.2 Yes 0
ERAP1-003 ENSP00000421697
ENST00000507154
D6RAL9
Show all »
Show » Show » 129 14.6 Yes 0
ERAP1-004 ENSP00000422631
ENST00000508227
Show » 9 1.1 No 0
ERAP1-005 ENSP00000427025
ENST00000503921
Show » 1 0.1 No 0
ERAP1-008 ENSP00000425381
ENST00000512852
Show » 144 16.9 No 0