GRIK2 - Gene info - The Human Protein Atlas

GRIK2

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	GRIK2 (HGNC Symbol)
Synonyms	GluK2, GLUR6, MRT6
Description	Glutamate receptor, ionotropic, kainate 2 (HGNC Symbol)
Entrez gene summary	Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q16.3
Chromosome location (bp)	101398788 - 102070083
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164418 (version 78.38)
Entrez gene	2898
UniProt	Q13002 (UniProt - Evidence at protein level)
neXtProt	NX_Q13002
Antibodypedia	GRIK2 antibodies

PROTEIN VIEW

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GRIK2-001		GRIK2-002		GRIK2-003		GRIK2-004		GRIK2-005		GRIK2-008		GRIK2-201		GRIK2-202		GRIK2-203

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
GRIK2-001	ENSP00000397026 ENST00000421544	Q13002 Show all » « Hide Q13002 [Direct mapping] Glutamate receptor ionotropic, kainate 2 F8WEZ8 [Target identity:94%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000358130} Q6P3V6 [Target identity:64%; Query identity:100%] GRIK2 protein {ECO:0000313\|EMBL:AAH63814.1} Q9BZ15 [Target identity:23%; Query identity:100%] BA487F5.1 (Glutamate receptor, ionotropic, kainate 2) {ECO:0000313\|EMBL:CAC25104.1} H7C2P5 [Target identity:20%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000407140} D7RWZ8 [Target identity:3%; Query identity:100%] Glutamate receptor {ECO:0000313\|EMBL:ADH93574.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014)	Show » « Hide GO:0001662 [behavioral fear response] GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006874 [cellular calcium ion homeostasis] GO:0006886 [intracellular protein transport] GO:0007165 [signal transduction] GO:0007215 [glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0008328 [ionotropic glutamate receptor complex] GO:0014069 [postsynaptic density] GO:0015277 [kainate selective glutamate receptor activity] GO:0016020 [membrane] GO:0019228 [neuronal action potential] GO:0030054 [cell junction] GO:0030165 [PDZ domain binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031624 [ubiquitin conjugating enzyme binding] GO:0031625 [ubiquitin protein ligase binding] GO:0032839 [dendrite cytoplasm] GO:0032983 [kainate selective glutamate receptor complex] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035249 [synaptic transmission, glutamatergic] GO:0042391 [regulation of membrane potential] GO:0042734 [presynaptic membrane] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0043113 [receptor clustering] GO:0043195 [terminal bouton] GO:0043204 [perikaryon] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043525 [positive regulation of neuron apoptotic process] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0046328 [regulation of JNK cascade] GO:0048169 [regulation of long-term neuronal synaptic plasticity] GO:0048172 [regulation of short-term neuronal synaptic plasticity] GO:0050804 [regulation of synaptic transmission] GO:0050806 [positive regulation of synaptic transmission] GO:0051402 [neuron apoptotic process] GO:0051967 [negative regulation of synaptic transmission, glutamatergic] GO:0060079 [regulation of excitatory postsynaptic membrane potential] GO:0060080 [regulation of inhibitory postsynaptic membrane potential]	908	102.6	Yes	3
GRIK2-002	ENSP00000405596 ENST00000413795	Q13002 Show all » « Hide Q13002 [Direct mapping] Glutamate receptor ionotropic, kainate 2 Q6P3V6 [Target identity:67%; Query identity:100%] GRIK2 protein {ECO:0000313\|EMBL:AAH63814.1} H7C2P5 [Target identity:20%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000407140} D7RWZ8 [Target identity:3%; Query identity:100%] Glutamate receptor {ECO:0000313\|EMBL:ADH93574.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014)	Show » « Hide GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0007215 [glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0015277 [kainate selective glutamate receptor activity] GO:0016020 [membrane] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0032983 [kainate selective glutamate receptor complex] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035249 [synaptic transmission, glutamatergic] GO:0042734 [presynaptic membrane] GO:0045211 [postsynaptic membrane] GO:0048172 [regulation of short-term neuronal synaptic plasticity] GO:0050804 [regulation of synaptic transmission] GO:0050806 [positive regulation of synaptic transmission]	869	98	Yes	3
GRIK2-003	ENSP00000358134 ENST00000369138	Q13002 Show all » « Hide Q13002 [Direct mapping] Glutamate receptor ionotropic, kainate 2 Q6P3V6 [Target identity:65%; Query identity:100%] GRIK2 protein {ECO:0000313\|EMBL:AAH63814.1} H7C2P5 [Target identity:20%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000407140} D7RWZ8 [Target identity:3%; Query identity:100%] Glutamate receptor {ECO:0000313\|EMBL:ADH93574.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014)	Show » « Hide GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0007215 [glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0015277 [kainate selective glutamate receptor activity] GO:0016020 [membrane] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0032983 [kainate selective glutamate receptor complex] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035249 [synaptic transmission, glutamatergic] GO:0042734 [presynaptic membrane] GO:0045211 [postsynaptic membrane] GO:0048172 [regulation of short-term neuronal synaptic plasticity] GO:0050804 [regulation of synaptic transmission] GO:0050806 [positive regulation of synaptic transmission]	892	100.2	Yes	3
GRIK2-004	ENSP00000391988 ENST00000455610	H7BZX7 Show all » « Hide H7BZX7 [Target identity:100%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000391988}	Show » « Hide MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway]	180	20.4	No	0
GRIK2-005	ENSP00000407140 ENST00000436862	H7C2P5 Show all » « Hide H7C2P5 [Target identity:100%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000407140}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway]	182	20.4	No	1
GRIK2-008	ENSP00000351128 ENST00000358361	G3XAD3 Show all » « Hide G3XAD3 [Target identity:100%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000351128}; Glutamate receptor, ionotropic, kainate 2, isoform CRA_b {ECO:0000313\|EMBL:EAW48447.1} D7RWZ8 [Target identity:9%; Query identity:100%] Glutamate receptor {ECO:0000313\|EMBL:ADH93574.1}	Show » « Hide MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0016021 [integral component of membrane]	353	39.9	Yes	0
GRIK2-201	ENSP00000313276 ENST00000318991	H7C2P5 Show all » « Hide H7C2P5 [Target identity:21%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000407140}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway]	854	95.8	No	3
GRIK2-202	ENSP00000358130 ENST00000369134	F8WEZ8 Show all » « Hide F8WEZ8 [Target identity:98%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000358130} Q9BZ15 [Target identity:24%; Query identity:100%] BA487F5.1 (Glutamate receptor, ionotropic, kainate 2) {ECO:0000313\|EMBL:CAC25104.1} H7C2P5 [Target identity:20%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000407140}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0016020 [membrane] GO:0030054 [cell junction] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway]	870	98.1	No	3
GRIK2-203	ENSP00000358133 ENST00000369137	H7C2P5 Show all » « Hide H7C2P5 [Target identity:21%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000407140}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway]	831	93.5	No	3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.