CAMLG

GENE INFORMATION

? »

Gene name

CAMLG (HGNC Symbol)

Synonyms

CAML

Description

Calcium modulating ligand (HGNC Symbol)

Entrez gene summary

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q31.1

Chromosome location (bp)

134738501 - 134752160

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164615 (version 78.38)

Entrez gene

819

UniProt

P49069 (UniProt - Evidence at protein level)

neXtProt

NX_P49069

Antibodypedia

CAMLG antibodies
 

PROTEIN VIEW

? »
 
 
 
CAMLG-001
 
CAMLG-002
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAMLG-001 ENSP00000297156
ENST00000297156
P49069
Show all »
Show » Show » 296 33 No 2
CAMLG-002 ENSP00000427331
ENST00000514518
D6RIW3
Show all »
Show » 80 8.8 No 0