DEFA6

GENE INFORMATION

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Gene name

DEFA6 (HGNC Symbol)

Synonyms

DEF6, HD-6

Description

Defensin, alpha 6, Paneth cell-specific (HGNC Symbol)

Entrez gene summary

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014]

Chromosome

8

Cytoband

p23.1

Chromosome location (bp)

6924693 - 6926076

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164822 (version 78.38)

Entrez gene

1671

UniProt

Q01524 (UniProt - Evidence at protein level)

neXtProt

NX_Q01524

Antibodypedia

DEFA6 antibodies
 

PROTEIN VIEW

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DEFA6-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DEFA6-001 ENSP00000297436
ENST00000297436
Q01524
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