BTRC

GENE INFORMATION

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Gene name

BTRC (HGNC Symbol)

Synonyms

beta-TrCP1, betaTrCP, bTrCP, bTrCP1, FBXW1A, Fwd1

Description

Beta-transducin repeat containing E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]

Chromosome

10

Cytoband

q24.32

Chromosome location (bp)

101354033 - 101557321

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166167 (version 78.38)

Entrez gene

8945

UniProt

Q9Y297 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y297

Antibodypedia

BTRC antibodies
 

PROTEIN VIEW

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BTRC-001
 
BTRC-002
 
BTRC-005
 
BTRC-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BTRC-001 ENSP00000359206
ENST00000370187
Q9Y297
Show all »
Show » Show » 605 68.9 No 0
BTRC-002 ENSP00000385339
ENST00000408038
Q9Y297
Show all »
Show » Show » 569 65 No 0
BTRC-005 ENSP00000359202
ENST00000370183
Q5T1W7
Show all »
Show » Show » 191 21.5 No 0
BTRC-201 ENSP00000377088
ENST00000393441
B7Z3H4
Show all »
Show » Show » 579 65.9 No 0