COX11

GENE INFORMATION

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Gene name

COX11 (HGNC Symbol)

Synonyms

COX11P

Description

Cytochrome c oxidase assembly homolog 11 (yeast) (HGNC Symbol)

Entrez gene summary

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009]

Chromosome

17

Cytoband

q22

Chromosome location (bp)

54951902 - 54968785

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166260 (version 78.38)

Entrez gene

1353

UniProt

Q9Y6N1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y6N1

Antibodypedia

COX11 antibodies
 

PROTEIN VIEW

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COX11-001
 
COX11-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COX11-001 ENSP00000299335
ENST00000299335
Q9Y6N1
Show all »
Show » Show » 276 31.4 No 1
COX11-002 ENSP00000460043
ENST00000571584
B4DI26
Show all »
Show » Show » 230 26 No 1