STAT6 - Gene info - The Human Protein Atlas

STAT6

TISSUE

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SUBCELL

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CELL LINE

CANCER

GENE INFORMATION

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Gene name	STAT6 (HGNC Symbol)
Synonyms	D12S1644, IL-4-STAT
Description	Signal transducer and activator of transcription 6, interleukin-4 induced (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Chromosome	12
Cytoband	q13.3
Chromosome location (bp)	57095408 - 57132139
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166888 (version 78.38)
Entrez gene	6778
UniProt	P42226 (UniProt - Evidence at protein level)
neXtProt	NX_P42226
Antibodypedia	STAT6 antibodies

PROTEIN VIEW

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STAT6-001		STAT6-002		STAT6-003		STAT6-004		STAT6-006		STAT6-008		STAT6-010		STAT6-013		STAT6-014		STAT6-015		STAT6-018		STAT6-019		STAT6-020		STAT6-021		STAT6-022		STAT6-023		STAT6-024

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
STAT6-001	ENSP00000300134 ENST00000300134	P42226 Show all » « Hide P42226 [Direct mapping] Signal transducer and activator of transcription 6 G3V2X7 [Target identity:18%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450921} G3V370 [Target identity:18%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000451074} G3V5K5 [Target identity:18%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000452394} G3V568 [Target identity:17%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000452203} G3V2H4 [Target identity:12%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450665} G3V3E9 [Target identity:12%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000451209} G3V2M3 [Target identity:8%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450747} G3V2L2 [Target identity:7%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450732} Q6LCD8 [Target identity:7%; Query identity:100%] STAT6 {ECO:0000313\|EMBL:AAC51204.1} Q5FBW6 [Target identity:4%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450510}; Signal transducer and activator of transcription 6 nirs variant 1 {ECO:0000313\|EMBL:BAD89431.1}	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0002296 [T-helper 1 cell lineage commitment] GO:0002829 [negative regulation of type 2 immune response] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0019221 [cytokine-mediated signaling pathway] GO:0019903 [protein phosphatase binding] GO:0032481 [positive regulation of type I interferon production] GO:0033598 [mammary gland epithelial cell proliferation] GO:0034097 [response to cytokine] GO:0035771 [interleukin-4-mediated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042802 [identical protein binding] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048295 [positive regulation of isotype switching to IgE isotypes] GO:0060443 [mammary gland morphogenesis] GO:0070301 [cellular response to hydrogen peroxide] GO:1902170 [cellular response to reactive nitrogen species]	847	94.1	No	0
STAT6-002	ENSP00000451742 ENST00000556155	P42226 Show all » « Hide P42226 [Direct mapping] Signal transducer and activator of transcription 6 G3V2X7 [Target identity:18%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450921} G3V370 [Target identity:18%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000451074} G3V5K5 [Target identity:18%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000452394} G3V568 [Target identity:17%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000452203} G3V2H4 [Target identity:12%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450665} G3V3E9 [Target identity:12%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000451209} G3V2M3 [Target identity:8%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450747} G3V2L2 [Target identity:7%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450732} Q6LCD8 [Target identity:7%; Query identity:100%] STAT6 {ECO:0000313\|EMBL:AAC51204.1} Q5FBW6 [Target identity:4%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450510}; Signal transducer and activator of transcription 6 nirs variant 1 {ECO:0000313\|EMBL:BAD89431.1}	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0019903 [protein phosphatase binding] GO:0032481 [positive regulation of type I interferon production] GO:0035771 [interleukin-4-mediated signaling pathway] GO:0042802 [identical protein binding] GO:0045087 [innate immune response]	847	94.1	No	0
STAT6-003	ENSP00000438451 ENST00000543873	P42226 Show all » « Hide P42226 [Direct mapping] Signal transducer and activator of transcription 6 G3V2X7 [Target identity:18%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450921} G3V370 [Target identity:18%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000451074} G3V5K5 [Target identity:18%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000452394} G3V568 [Target identity:17%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000452203} G3V2H4 [Target identity:12%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450665} G3V3E9 [Target identity:12%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000451209} G3V2M3 [Target identity:8%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450747} G3V2L2 [Target identity:7%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450732} Q6LCD8 [Target identity:7%; Query identity:100%] STAT6 {ECO:0000313\|EMBL:AAC51204.1} Q5FBW6 [Target identity:4%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450510}; Signal transducer and activator of transcription 6 nirs variant 1 {ECO:0000313\|EMBL:BAD89431.1}	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0019903 [protein phosphatase binding] GO:0032481 [positive regulation of type I interferon production] GO:0035771 [interleukin-4-mediated signaling pathway] GO:0042802 [identical protein binding] GO:0045087 [innate immune response]	847	94.1	No	0
STAT6-004	ENSP00000401486 ENST00000454075	P42226 Show all » « Hide P42226 [Direct mapping] Signal transducer and activator of transcription 6 G3V2X7 [Target identity:18%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450921} G3V370 [Target identity:18%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000451074} G3V5K5 [Target identity:18%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000452394} G3V568 [Target identity:17%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000452203} G3V2H4 [Target identity:12%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450665} G3V3E9 [Target identity:12%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000451209} G3V2M3 [Target identity:8%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450747} G3V2L2 [Target identity:7%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450732} Q6LCD8 [Target identity:7%; Query identity:100%] STAT6 {ECO:0000313\|EMBL:AAC51204.1} Q5FBW6 [Target identity:4%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450510}; Signal transducer and activator of transcription 6 nirs variant 1 {ECO:0000313\|EMBL:BAD89431.1}	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0019903 [protein phosphatase binding] GO:0032481 [positive regulation of type I interferon production] GO:0035771 [interleukin-4-mediated signaling pathway] GO:0042802 [identical protein binding] GO:0045087 [innate immune response]	847	94.1	No	0
STAT6-006	ENSP00000444530 ENST00000537215	P42226 Show all » « Hide P42226 [Direct mapping] Signal transducer and activator of transcription 6 G3V2X7 [Target identity:20%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450921} Q6LCD8 [Target identity:8%; Query identity:100%] STAT6 {ECO:0000313\|EMBL:AAC51204.1}	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0019903 [protein phosphatase binding] GO:0032481 [positive regulation of type I interferon production] GO:0035771 [interleukin-4-mediated signaling pathway] GO:0042802 [identical protein binding] GO:0045087 [innate immune response]	737	81.7	No	0
STAT6-008	ENSP00000445409 ENST00000538913	P42226 Show all » « Hide P42226 [Direct mapping] Signal transducer and activator of transcription 6 G3V2X7 [Target identity:20%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450921} Q6LCD8 [Target identity:8%; Query identity:100%] STAT6 {ECO:0000313\|EMBL:AAC51204.1}	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0019903 [protein phosphatase binding] GO:0032481 [positive regulation of type I interferon production] GO:0035771 [interleukin-4-mediated signaling pathway] GO:0042802 [identical protein binding] GO:0045087 [innate immune response]	737	81.7	No	0
STAT6-010	ENSP00000451074 ENST00000553499	G3V370 Show all » « Hide G3V370 [Target identity:100%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000451074} G3V568 [Target identity:93%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000452203} G3V2H4 [Target identity:67%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450665} G3V3E9 [Target identity:66%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000451209} G3V2M3 [Target identity:48%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450747} G3V2L2 [Target identity:41%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450732} Q5FBW6 [Target identity:24%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450510}; Signal transducer and activator of transcription 6 nirs variant 1 {ECO:0000313\|EMBL:BAD89431.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction]	154	17.8	No	0
STAT6-013	ENSP00000450428 ENST00000555318	H0YIY2 Show all » « Hide H0YIY2 [Target identity:100%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450428}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction]	155	17.3	No	0
STAT6-014	ENSP00000451546 ENST00000553533		Show » « Hide SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction]	290	32.5	No	0
STAT6-015	ENSP00000450921 ENST00000555375	G3V2X7 Show all » « Hide G3V2X7 [Target identity:100%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450921}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction]	154	17.9	No	0
STAT6-018	ENSP00000450732 ENST00000553275	G3V2L2 Show all » « Hide G3V2L2 [Target identity:100%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450732} Q5FBW6 [Target identity:59%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450510}; Signal transducer and activator of transcription 6 nirs variant 1 {ECO:0000313\|EMBL:BAD89431.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction]	64	7.4	No	0
STAT6-019	ENSP00000451209 ENST00000554825	G3V3E9 Show all » « Hide G3V3E9 [Target identity:100%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000451209} G3V2M3 [Target identity:71%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450747} G3V2L2 [Target identity:62%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450732} Q5FBW6 [Target identity:36%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450510}; Signal transducer and activator of transcription 6 nirs variant 1 {ECO:0000313\|EMBL:BAD89431.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction]	103	11.7	No	0
STAT6-020	ENSP00000452203 ENST00000553397	G3V568 Show all » « Hide G3V568 [Target identity:100%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000452203} G3V2H4 [Target identity:72%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450665} G3V3E9 [Target identity:71%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000451209} G3V2M3 [Target identity:51%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450747} G3V2L2 [Target identity:44%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450732} Q5FBW6 [Target identity:26%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450510}; Signal transducer and activator of transcription 6 nirs variant 1 {ECO:0000313\|EMBL:BAD89431.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction]	144	16.7	No	0
STAT6-021	ENSP00000452394 ENST00000555849	G3V5K5 Show all » « Hide G3V5K5 [Target identity:100%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000452394} G3V370 [Target identity:96%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000451074} G3V568 [Target identity:90%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000452203} G3V2H4 [Target identity:65%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450665} G3V3E9 [Target identity:64%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000451209} G3V2M3 [Target identity:46%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450747} G3V2L2 [Target identity:40%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450732} Q5FBW6 [Target identity:23%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450510}; Signal transducer and activator of transcription 6 nirs variant 1 {ECO:0000313\|EMBL:BAD89431.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction]	159	18.3	No	0
STAT6-022	ENSP00000450747 ENST00000557635	G3V2M3 Show all » « Hide G3V2M3 [Target identity:100%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450747} G3V2L2 [Target identity:86%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450732} Q5FBW6 [Target identity:51%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450510}; Signal transducer and activator of transcription 6 nirs variant 1 {ECO:0000313\|EMBL:BAD89431.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction]	74	8.3	No	0
STAT6-023	ENSP00000450665 ENST00000554663	G3V2H4 Show all » « Hide G3V2H4 [Target identity:99%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450665} G3V3E9 [Target identity:98%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000451209} G3V2M3 [Target identity:70%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450747} G3V2L2 [Target identity:60%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450732} Q5FBW6 [Target identity:36%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450510}; Signal transducer and activator of transcription 6 nirs variant 1 {ECO:0000313\|EMBL:BAD89431.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction]	105	11.8	No	0
STAT6-024	ENSP00000452373 ENST00000556259	G3V5I8 Show all » « Hide G3V5I8 [Target identity:100%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000452373} G3V2L2 [Target identity:45%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450732} Q5FBW6 [Target identity:26%; Query identity:100%] Signal transducer and activator of transcription 6 {ECO:0000313\|Ensembl:ENSP00000450510}; Signal transducer and activator of transcription 6 nirs variant 1 {ECO:0000313\|EMBL:BAD89431.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004871 [signal transducer activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction]	141	16.4	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.