PDIA3

GENE INFORMATION

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Gene name

PDIA3 (HGNC Symbol)

Synonyms

ERp57, ERp60, ERp61, GRP57, GRP58, HsT17083, P58, PI-PLC

Description

Protein disulfide isomerase family A, member 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q15.3

Chromosome location (bp)

43746392 - 43773279

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167004 (version 78.38)

Entrez gene

2923

UniProt

P30101 (UniProt - Evidence at protein level)

neXtProt

NX_P30101

Antibodypedia

PDIA3 antibodies
 

PROTEIN VIEW

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PDIA3-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDIA3-001 ENSP00000300289
ENST00000300289
P30101
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