RRM1

GENE INFORMATION

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Gene name

RRM1

Synonyms

Description

Ribonucleotide reductase M1 (HGNC Symbol)

Entrez gene summary

This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

4094707 - 4138876

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167325 (version 78.38)

Entrez gene

6240

UniProt

P23921 (UniProt - Evidence at protein level)

neXtProt

NX_P23921

Antibodypedia

RRM1 antibodies
 

PROTEIN VIEW

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RRM1-001
 
RRM1-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RRM1-001 ENSP00000300738
ENST00000300738
P23921
Show all »
Show » Show » 792 90.1 No 0
RRM1-005 ENSP00000431464
ENST00000534285
E9PL69
Show all »
Show » Show » 570 64.8 No 0