GPX4

GENE INFORMATION

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Gene name

GPX4 (HGNC Symbol)

Synonyms

MCSP, PHGPx

Description

Glutathione peroxidase 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

1103926 - 1106791

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167468 (version 78.38)

Entrez gene

2879

UniProt

P36969 (UniProt - Evidence at protein level)

neXtProt

NX_P36969

Antibodypedia

GPX4 antibodies
 

PROTEIN VIEW

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GPX4-002
 
GPX4-003
 
GPX4-004
 
GPX4-006
 
GPX4-007
 
GPX4-009
 
GPX4-010
 
GPX4-011
 
GPX4-201
 
GPX4-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GPX4-002 ENSP00000346103
ENST00000354171
P36969
Show all »
Show » Show » 197 22.2 Yes 0
GPX4-003 ENSP00000464989
ENST00000588919
Show » Show » 260 28.4 Yes 0
GPX4-004 ENSP00000473614
ENST00000585362
Show » Show » 180 20.7 No 0
GPX4-006 ENSP00000465828
ENST00000593032
Show » Show » 195 21.7 Yes 0
GPX4-007 ENSP00000466872
ENST00000589115
Show » Show » 180 20.1 Yes 0
GPX4-009 ENSP00000468349
ENST00000587648
Show » Show » 155 17.7 No 0
GPX4-010 ENSP00000484697
ENST00000614791
Show » Show » 134 15.5 No 0
GPX4-011 ENSP00000483655
ENST00000611653
P36969
Show all »
Show » Show » 170 19.5 No 0
GPX4-201 ENSP00000485000
ENST00000616066
Q6PJX4
Show all »
Show » Show » 196 22 Yes 0
GPX4-202 ENSP00000477503
ENST00000622390
Q6PJX4
Show all »
Show » Show » 233 26.9 No 0