GPD1

GENE INFORMATION

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Gene name

GPD1

Synonyms

Description

Glycerol-3-phosphate dehydrogenase 1 (soluble) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Chromosome

12

Cytoband

q13.12

Chromosome location (bp)

50103819 - 50111319

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167588 (version 78.38)

Entrez gene

2819

UniProt

P21695 (UniProt - Evidence at protein level)

neXtProt

NX_P21695

Antibodypedia

GPD1 antibodies
 

PROTEIN VIEW

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GPD1-001
 
GPD1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GPD1-001 ENSP00000301149
ENST00000301149
P21695
Show all »
Show » Show » 349 37.6 No 0
GPD1-002 ENSP00000446768
ENST00000548814
P21695
Show all »
Show » Show » 326 35.1 No 0