LAIR1

GENE INFORMATION

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Gene name

LAIR1 (HGNC Symbol)

Synonyms

CD305

Description

Leukocyte-associated immunoglobulin-like receptor 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Chromosome

19

Cytoband

q13.42

Chromosome location (bp)

54351384 - 54370558

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167613 (version 78.38)

Entrez gene

3903

UniProt

Q6GTX8 (UniProt - Evidence at protein level)

neXtProt

NX_Q6GTX8

Antibodypedia

LAIR1 antibodies
 

PROTEIN VIEW

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LAIR1-001
 
LAIR1-002
 
LAIR1-003
 
LAIR1-004
 
LAIR1-005
 
LAIR1-015
 
LAIR1-016
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LAIR1-001 ENSP00000375622
ENST00000391742
Q6GTX8
Show all »
Show » Show » 287 31.5 Yes 1
LAIR1-002 ENSP00000391003
ENST00000434277
Show » 286 31.3 Yes 1
LAIR1-003 ENSP00000301193
ENST00000348231
Q6GTX8
Show all »
Show » Show » 270 29.9 Yes 1
LAIR1-004 ENSP00000418998
ENST00000474878
Q6GTX8
Show all »
Show » Show » 269 29.8 Yes 1
LAIR1-005 ENSP00000375623
ENST00000391743
Show » 269 29.7 No 1
LAIR1-015 ENSP00000392058
ENST00000438193
Show » 93 10.3 No 0
LAIR1-016 ENSP00000483867
ENST00000622064
Show » 79 8.5 No 0