KIR3DL1

GENE INFORMATION

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Gene name

KIR3DL1 (HGNC Symbol)

Synonyms

AMB11, CD158E1, CD158e1/2, CD158e2, cl-11, cl-2, KIR, nkat3, NKB1, NKB1B

Description

Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 (HGNC Symbol)

Entrez gene summary

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several ""framework"" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.42

Chromosome location (bp)

54724497 - 54867215

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167633 (version 78.38)

Entrez gene

3811

UniProt

P43629 (UniProt - Evidence at protein level)

neXtProt

NX_P43629

Antibodypedia

KIR3DL1 antibodies
 

PROTEIN VIEW

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KIR3DL1-001
 
KIR3DL1-002
 
KIR3DL1-003
 
KIR3DL1-201
 
KIR3DL1-202
 
KIR3DL1-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KIR3DL1-001 ENSP00000375608
ENST00000391728
P43629
Show all »
Show » Show » 444 49.1 Yes 1
KIR3DL1-002 ENSP00000350901
ENST00000358178
P43629
Show all »
Show » Show » 349 38.4 Yes 1
KIR3DL1-003 ENSP00000326868
ENST00000326542
W4VSQ6
Show all »
Show » 427 47.4 Yes 1
KIR3DL1-201 ENSP00000384528
ENST00000402254
F6QF33
Show all »
Show » 455 50.4 Yes 1
KIR3DL1-202 ENSP00000443350
ENST00000538269
F6QF33
Show all »
Show » 455 50.4 Yes 1
KIR3DL1-203 ENSP00000442355
ENST00000541392
F6QF33
Show all »
Show » 455 50.4 Yes 1