SPINT2

GENE INFORMATION

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Gene name

SPINT2 (HGNC Symbol)

Synonyms

HAI-2, Kop

Description

Serine peptidase inhibitor, Kunitz type, 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Chromosome

19

Cytoband

q13.2

Chromosome location (bp)

38244035 - 38292614

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167642 (version 78.38)

Entrez gene

10653

UniProt

O43291 (UniProt - Evidence at protein level)

neXtProt

NX_O43291

Antibodypedia

SPINT2 antibodies
 

PROTEIN VIEW

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SPINT2-001
 
SPINT2-002
 
SPINT2-004
 
SPINT2-005
 
SPINT2-006
 
SPINT2-009
 
SPINT2-010
 
SPINT2-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPINT2-001 ENSP00000301244
ENST00000301244
O43291
Show all »
Show » Show » 252 28.2 Yes 1
SPINT2-002 ENSP00000389788
ENST00000454580
O43291
Show all »
Show » Show » 195 21.8 Yes 1
SPINT2-004 ENSP00000466407
ENST00000587090
K7EM91
Show all »
Show » Show » 202 22.8 No 1
SPINT2-005 ENSP00000465561
ENST00000592007
K7EKC8
Show all »
Show » Show » 62 6.7 No 0
SPINT2-006 ENSP00000465721
ENST00000587516
K7EKQ0
Show all »
Show » Show » 175 19.8 Yes 0
SPINT2-009 ENSP00000468728
ENST00000590738
Show » Show » 130 14.7 No 0
SPINT2-010 ENSP00000468519
ENST00000587334
Show » 106 11.2 No 1
SPINT2-011 ENSP00000465301
ENST00000590510
K7EJS4
Show all »
Show » Show » 52 5.8 No 0