KLK2

GENE INFORMATION

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Gene name

KLK2

Synonyms

Description

Kallikrein-related peptidase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]

Chromosome

19

Cytoband

q13.33

Chromosome location (bp)

50861568 - 50880567

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167751 (version 78.38)

Entrez gene

3817

UniProt

P20151 (UniProt - Evidence at protein level)

neXtProt

NX_P20151

Antibodypedia

KLK2 antibodies
 

PROTEIN VIEW

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KLK2-001
 
KLK2-003
 
KLK2-015
 
KLK2-016
 
KLK2-019
 
KLK2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KLK2-001 ENSP00000313581
ENST00000325321
P20151
Show all »
Show » Show » 261 28.7 Yes 0
KLK2-003 ENSP00000350748
ENST00000358049
A0A024R4N3
Show all »
Show » Show » 223 24.7 Yes 0
KLK2-015 ENSP00000469318
ENST00000600690
M0QXQ7
Show all »
Show » Show » 122 13.1 Yes 0
KLK2-016 ENSP00000472852
ENST00000593493
M0R2W5
Show all »
Show » 23 2.7 No 0
KLK2-019 ENSP00000471323
ENST00000599568
M0R0M4
Show all »
Show » Show » 44 4.9 No 0
KLK2-201 ENSP00000375686
ENST00000391810
B0AZU9
Show all »
Show » Show » 159 17.3 No 0