OTUB1

GENE INFORMATION

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Gene name

OTUB1 (HGNC Symbol)

Synonyms

FLJ20113, FLJ40710

Description

OTU deubiquitinase, ubiquitin aldehyde binding 1 (HGNC Symbol)

Entrez gene summary

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q13.1

Chromosome location (bp)

63985853 - 64001811

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167770 (version 78.38)

Entrez gene

55611

UniProt

Q96FW1 (UniProt - Evidence at protein level)

neXtProt

NX_Q96FW1

Antibodypedia

OTUB1 antibodies
 

PROTEIN VIEW

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OTUB1-001
 
OTUB1-003
 
OTUB1-005
 
OTUB1-008
 
OTUB1-010
 
OTUB1-012
 
OTUB1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OTUB1-001 ENSP00000444357
ENST00000538426
Q96FW1
Show all »
Show » Show » 271 31.3 No 0
OTUB1-003 ENSP00000441328
ENST00000543988
F5GYN4
Show all »
Show » Show » 241 28.1 No 0
OTUB1-005 ENSP00000439142
ENST00000541478
F5H3F0
Show all »
Show » 170 19.4 No 0
OTUB1-008 ENSP00000437453
ENST00000543004
F5H6Q1
Show all »
Show » Show » 280 32.3 No 0
OTUB1-010 ENSP00000440211
ENST00000535715
F5GYJ8
Show all »
Show » Show » 286 32.4 No 0
OTUB1-012 ENSP00000402551
ENST00000428192
Q96FW1
Show all »
Show » Show » 271 31.3 No 0
OTUB1-201 ENSP00000416973
ENST00000422031
Show » Show » 272 31.4 No 0