ANGPTL4

GENE INFORMATION

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Gene name

ANGPTL4 (HGNC Symbol)

Synonyms

ARP4, FIAF, HFARP, NL2, PGAR, pp1158

Description

Angiopoietin-like 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

Chromosome

19

Cytoband

p13.2

Chromosome location (bp)

8363289 - 8374373

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167772 (version 78.38)

Entrez gene

51129

UniProt

Q9BY76 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BY76

Antibodypedia

ANGPTL4 antibodies
 

PROTEIN VIEW

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ANGPTL4-001
 
ANGPTL4-002
 
ANGPTL4-005
 
ANGPTL4-006
 
ANGPTL4-007
 
ANGPTL4-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ANGPTL4-001 ENSP00000301455
ENST00000301455
Q9BY76
Show all »
Show » Show » 406 45.2 Yes 0
ANGPTL4-002 ENSP00000377534
ENST00000393962
Q9BY76
Show all »
Show » Show » 368 40.9 Yes 0
ANGPTL4-005 ENSP00000471345
ENST00000601770
M0R0N8
Show all »
Show » Show » 86 8.8 Yes 0
ANGPTL4-006 ENSP00000470307
ENST00000601886
M0QZ51
Show all »
Show » Show » 96 9.9 Yes 0
ANGPTL4-007 ENSP00000473090
ENST00000599192
M0R3A2
Show all »
Show » Show » 105 10.9 Yes 0
ANGPTL4-008 ENSP00000472869
ENST00000594875
Show » 129 14.3 No 0