TMC8

GENE INFORMATION

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Gene name

TMC8 (HGNC Symbol)

Synonyms

EVER2, EVIN2

Description

Transmembrane channel-like 8 (HGNC Symbol)

Entrez gene summary

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q25.3

Chromosome location (bp)

78130770 - 78142968

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167895 (version 78.38)

Entrez gene

147138

UniProt

Q8IU68 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8IU68

Antibodypedia

TMC8 antibodies
 

PROTEIN VIEW

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TMC8-002
 
TMC8-003
 
TMC8-006
 
TMC8-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TMC8-002 ENSP00000325561
ENST00000318430
Q8IU68
Show all »
Show » Show » 726 81.6 No 9
TMC8-003 ENSP00000467482
ENST00000589691
Q8IU68
Show all »
Show » Show » 503 56.1 No 7
TMC8-006 ENSP00000465049
ENST00000590799
K7EJ72
Show all »
Show » 196 21.9 No 0
TMC8-012 ENSP00000467460
ENST00000590426
Show » 2 0.3 No 0