SFTPC

GENE INFORMATION

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Gene name

SFTPC (HGNC Symbol)

Synonyms

BRICD6, PSP-C, SFTP2, SMDP2, SP-C

Description

Surfactant protein C (HGNC Symbol)

Entrez gene summary

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010]

Chromosome

8

Cytoband

p21.3

Chromosome location (bp)

22156913 - 22164479

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168484 (version 78.38)

Entrez gene

6440

UniProt

P11686 (UniProt - Evidence at protein level)

neXtProt

NX_P11686

Antibodypedia

SFTPC antibodies
 

PROTEIN VIEW

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SFTPC-001
 
SFTPC-003
 
SFTPC-006
 
SFTPC-007
 
SFTPC-008
 
SFTPC-009
 
SFTPC-010
 
SFTPC-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SFTPC-001 ENSP00000316152
ENST00000318561
P11686
Show all »
Show » Show » 197 21 No 0
SFTPC-003 ENSP00000430410
ENST00000521315
Show » Show » 191 20.3 No 0
SFTPC-006 ENSP00000430266
ENST00000520605
E5RG20
Show all »
Show » Show » 155 17.4 No 0
SFTPC-007 ENSP00000429552
ENST00000524255
E5RI64
Show all »
Show » Show » 144 15.3 No 0
SFTPC-008 ENSP00000429619
ENST00000523296
E5RHW5
Show all »
Show » Show » 125 13.1 No 0
SFTPC-009 ENSP00000428817
ENST00000518615
E5RG93
Show all »
Show » Show » 119 12.8 No 0
SFTPC-010 ENSP00000429496
ENST00000522109
E5RI92
Show all »
Show » Show » 150 16.2 No 0
SFTPC-011 ENSP00000407931
ENST00000437090
C9JYF6
Show all »
Show » Show » 161 17.7 No 0