SFTPB

GENE INFORMATION

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Gene name

SFTPB (HGNC Symbol)

Synonyms

SFTP3, SP-B

Description

Surfactant protein B (HGNC Symbol)

Entrez gene summary

This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, Feb 2010]

Chromosome

2

Cytoband

p11.2

Chromosome location (bp)

85657314 - 85668741

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168878 (version 78.38)

Entrez gene

6439

UniProt

P07988 (UniProt - Evidence at protein level)

neXtProt

NX_P07988

Antibodypedia

SFTPB antibodies
 

PROTEIN VIEW

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SFTPB-001
 
SFTPB-002
 
SFTPB-003
 
SFTPB-007
 
SFTPB-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SFTPB-001 ENSP00000428719
ENST00000519937
P07988
Show all »
Show » Show » 381 42.1 Yes 0
SFTPB-002 ENSP00000415347
ENST00000428225
Show » Show » 374 41.4 Yes 0
SFTPB-003 ENSP00000386346
ENST00000409383
D6W5L6
Show all »
Show » Show » 393 43.3 Yes 0
SFTPB-007 ENSP00000476194
ENST00000494165
Show » 92 10 No 0
SFTPB-201 ENSP00000377409
ENST00000393822
P07988
Show all »
Show » Show » 381 42.1 Yes 0