CXCL11

GENE INFORMATION

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Gene name

CXCL11 (HGNC Symbol)

Synonyms

b-R1, H174, I-TAC, IP-9, SCYB11, SCYB9B

Description

Chemokine (C-X-C motif) ligand 11 (HGNC Symbol)

Entrez gene summary

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

Chromosome

4

Cytoband

q21.1

Chromosome location (bp)

76033682 - 76041415

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169248 (version 78.38)

Entrez gene

6373

UniProt

O14625 (UniProt - Evidence at protein level)

neXtProt

NX_O14625

Antibodypedia

CXCL11 antibodies
 

PROTEIN VIEW

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CXCL11-001
 
CXCL11-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CXCL11-001 ENSP00000306884
ENST00000306621
O14625
Show all »
Show » Show » 94 10.4 Yes 0
CXCL11-003 ENSP00000425819
ENST00000503860
O14625
Show all »
Show » Show » 94 10.4 Yes 0