PTAFR

GENE INFORMATION

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Gene name

PTAFR

Synonyms

Description

Platelet-activating factor receptor (HGNC Symbol)

Entrez gene summary

This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Chromosome

1

Cytoband

p35.3

Chromosome location (bp)

28147166 - 28193936

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169403 (version 78.38)

Entrez gene

5724

UniProt

P25105 (UniProt - Evidence at protein level)

neXtProt

NX_P25105

Antibodypedia

PTAFR antibodies
 

PROTEIN VIEW

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PTAFR-001
 
PTAFR-002
 
PTAFR-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTAFR-001 ENSP00000362965
ENST00000373857
P25105
Show all »
Show » Show » 342 39.2 No 7
PTAFR-002 ENSP00000301974
ENST00000305392
P25105
Show all »
Show » Show » 342 39.2 No 7
PTAFR-201 ENSP00000442658
ENST00000539896
P25105
Show all »
Show » Show » 342 39.2 No 7