HTRA4

GENE INFORMATION

? »

Gene name

HTRA4 (HGNC Symbol)

Synonyms

FLJ90724

Description

HtrA serine peptidase 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]

Chromosome

8

Cytoband

p11.22

Chromosome location (bp)

38974164 - 38988662

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169495 (version 78.38)

Entrez gene

203100

UniProt

P83105 (UniProt - Evidence at transcript level)

neXtProt

NX_P83105

Antibodypedia

HTRA4 antibodies
 

PROTEIN VIEW

? »
 
 
 
HTRA4-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HTRA4-001 ENSP00000305919
ENST00000302495
P83105
Show all »
Show » Show » 476 51 Yes 0