ITGAM

GENE INFORMATION

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Gene name

ITGAM (HGNC Symbol)

Synonyms

CD11B, CR3A, MAC-1

Description

Integrin, alpha M (complement component 3 receptor 3 subunit) (HGNC Symbol)

Entrez gene summary

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

16

Cytoband

p11.2

Chromosome location (bp)

31259990 - 31332892

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169896 (version 78.38)

Entrez gene

3684

UniProt

P11215 (UniProt - Evidence at protein level)

neXtProt

NX_P11215

Antibodypedia

ITGAM antibodies
 

PROTEIN VIEW

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ITGAM-001
 
ITGAM-002
 
ITGAM-003
 
ITGAM-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITGAM-001 ENSP00000441691
ENST00000544665
P11215
Show all »
Show » Show » 1153 127.3 Yes 1
ITGAM-002 ENSP00000287497
ENST00000287497
P11215
Show all »
Show » Show » 1152 127.2 Yes 1
ITGAM-003 ENSP00000454568
ENST00000567031
Show » 165 18.1 No 0
ITGAM-008 ENSP00000461850
ENST00000565142
I3NI33
Show all »
Show » 117 12.3 No 1