GUSB

GENE INFORMATION

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Gene name

GUSB

Synonyms

Description

Glucuronidase, beta (HGNC Symbol)

Entrez gene summary

This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]

Chromosome

7

Cytoband

q11.21

Chromosome location (bp)

65960684 - 65982314

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169919 (version 78.38)

Entrez gene

2990

UniProt

P08236 (UniProt - Evidence at protein level)

neXtProt

NX_P08236

Antibodypedia

GUSB antibodies
 

PROTEIN VIEW

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GUSB-001
 
GUSB-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GUSB-001 ENSP00000302728
ENST00000304895
P08236
Show all »
Show » Show » 651 74.7 Yes 0
GUSB-002 ENSP00000391390
ENST00000421103
P08236
Show all »
Show » Show » 505 58.3 Yes 0