PDCD6IP

GENE INFORMATION

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Gene name

PDCD6IP (HGNC Symbol)

Synonyms

AIP1, Alix, Hp95

Description

Programmed cell death 6 interacting protein (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]

Chromosome

3

Cytoband

p22.3

Chromosome location (bp)

33798352 - 33869707

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170248 (version 78.38)

Entrez gene

10015

UniProt

Q8WUM4 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WUM4

Antibodypedia

PDCD6IP antibodies
 

PROTEIN VIEW

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PDCD6IP-001
 
PDCD6IP-006
 
PDCD6IP-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDCD6IP-001 ENSP00000307387
ENST00000307296
Q8WUM4
Show all »
Show » Show » 868 96 No 0
PDCD6IP-006 ENSP00000406693
ENST00000413073
C9IZF9
Show all »
Show » 153 17.1 No 0
PDCD6IP-201 ENSP00000411825
ENST00000457054
Q8WUM4
Show all »
Show » Show » 873 96.8 No 0