RBMXL2

GENE INFORMATION

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Gene name

RBMXL2 (HGNC Symbol)

Synonyms

HNRNPG-T, HNRPGT

Description

RNA binding motif protein, X-linked-like 2 (HGNC Symbol)

Entrez gene summary

This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon. However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

7089027 - 7090900

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170748 (version 78.38)

Entrez gene

27288

UniProt

O75526 (UniProt - Evidence at protein level)

neXtProt

NX_O75526

Antibodypedia

RBMXL2 antibodies
 

PROTEIN VIEW

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RBMXL2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RBMXL2-001 ENSP00000304139
ENST00000306904
O75526
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