HDAC3

GENE INFORMATION

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Gene name

HDAC3 (HGNC Symbol)

Synonyms

HD3, RPD3, RPD3-2

Description

Histone deacetylase 3 (HGNC Symbol)

Entrez gene summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q31.3

Chromosome location (bp)

141620876 - 141636870

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171720 (version 78.38)

Entrez gene

8841

UniProt

O15379 (UniProt - Evidence at protein level)

neXtProt

NX_O15379

Antibodypedia

HDAC3 antibodies
 

PROTEIN VIEW

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HDAC3-001
 
HDAC3-016
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HDAC3-001 ENSP00000302967
ENST00000305264
O15379
Show all »
Show » Show » 428 48.8 No 0
HDAC3-016 ENSP00000429099
ENST00000523088
E7ESJ6
Show all »
Show » Show » 219 24.8 No 0