RNASEH1

GENE INFORMATION

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Gene name

RNASEH1

Synonyms

Description

Ribonuclease H1 (HGNC Symbol)

Entrez gene summary

This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and is necessary for DNA replication and repair. This enzyme is present in both mitochondria and nuclei, which are resulted from translation of a single mRNA with two in-frame initiation start codons. The use of the first start codon produces the mitochondrial isoform and the use of the second start codon produces the nuclear isoform. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF) which overlaps the first initiation start codon in human. An alternately spliced transcript variant has been found which encodes a shorter isoform. This gene has three pseudogenes; two of them are at different locations of chromosome 17 and one of them is on chromosome 1q32.2. [provided by RefSeq, Sep 2014]

Chromosome

2

Cytoband

p25.3

Chromosome location (bp)

3544793 - 3558616

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171865 (version 78.38)

Entrez gene

246243

UniProt

O60930 (UniProt - Evidence at protein level)

neXtProt

NX_O60930

Antibodypedia

RNASEH1 antibodies
 

PROTEIN VIEW

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RNASEH1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RNASEH1-001 ENSP00000313350
ENST00000315212
O60930
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