CD8B

GENE INFORMATION

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Gene name

CD8B (HGNC Symbol)

Synonyms

CD8B1

Description

CD8b molecule (HGNC Symbol)

Entrez gene summary

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]

Chromosome

2

Cytoband

p11.2

Chromosome location (bp)

86815339 - 86861924

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000172116 (version 78.38)

Entrez gene

926

UniProt

P10966 (UniProt - Evidence at protein level)

neXtProt

NX_P10966

Antibodypedia

CD8B antibodies
 

PROTEIN VIEW

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CD8B-001
 
CD8B-002
 
CD8B-003
 
CD8B-004
 
CD8B-201
 
CD8B-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD8B-001 ENSP00000375070
ENST00000390655
P10966
Show all »
Show » Show » 210 23.7 Yes 1
CD8B-002 ENSP00000331172
ENST00000331469
P10966
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Show » Show » 243 27.2 Yes 1
CD8B-003 ENSP00000377356
ENST00000393759
P10966
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Show » Show » 221 25 Yes 1
CD8B-004 ENSP00000340592
ENST00000349455
P10966
Show all »
Show » Show » 213 24.3 Yes 0
CD8B-201 ENSP00000377358
ENST00000393761
P10966
Show all »
Show » Show » 198 22.2 Yes 0
CD8B-202 ENSP00000394806
ENST00000431506
B4E0F8
Show all »
Show » Show » 210 23.7 Yes 1