CLEC7A

GENE INFORMATION

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Gene name

CLEC7A (HGNC Symbol)

Synonyms

CLECSF12, dectin-1, hDectin-1

Description

C-type lectin domain family 7, member A (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p13.2

Chromosome location (bp)

10116777 - 10130258

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000172243 (version 78.38)

Entrez gene

64581

UniProt

Q9BXN2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BXN2

Antibodypedia

CLEC7A antibodies
 

PROTEIN VIEW

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CLEC7A-001
 
CLEC7A-003
 
CLEC7A-004
 
CLEC7A-009
 
CLEC7A-012
 
CLEC7A-013
 
CLEC7A-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLEC7A-001 ENSP00000266456
ENST00000353231
Q9BXN2
Show all »
Show » Show » 201 22.6 No 1
CLEC7A-003 ENSP00000312089
ENST00000310002
Q9BXN2
Show all »
Show » Show » 77 8.4 No 1
CLEC7A-004 ENSP00000379743
ENST00000396484
Q9BXN2
Show all »
Show » Show » 168 19.2 No 0
CLEC7A-009 ENSP00000431461
ENST00000533022
Q9BXN2
Show all »
Show » Show » 189 21.1 No 1
CLEC7A-012 ENSP00000298523
ENST00000298523
Q9BXN2
Show all »
Show » Show » 143 16 No 1
CLEC7A-013 ENSP00000302569
ENST00000304084
Q9BXN2
Show all »
Show » Show » 247 27.6 No 1
CLEC7A-014 ENSP00000434954
ENST00000525605
Q68D78
Show all »
Show » Show » 136 15.6 No 2