B3GALT1

GENE INFORMATION

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Gene name

B3GALT1 (HGNC Symbol)

Synonyms

beta3Gal-T1

Description

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 (HGNC Symbol)

Entrez gene summary

This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is expressed exclusively in the brain. The encoded protein shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q24.3

Chromosome location (bp)

167868948 - 167874041

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000172318 (version 78.38)

Entrez gene

8708

UniProt

Q9Y5Z6 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9Y5Z6

Antibodypedia

B3GALT1 antibodies
 

PROTEIN VIEW

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B3GALT1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

B3GALT1-001 ENSP00000376456
ENST00000392690
Q9Y5Z6
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