CYP7B1

GENE INFORMATION

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Gene name

CYP7B1 (HGNC Symbol)

Synonyms

SPG5A

Description

Cytochrome P450, family 7, subfamily B, polypeptide 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

q12.3

Chromosome location (bp)

64587763 - 64798761

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000172817 (version 78.38)

Entrez gene

9420

UniProt

O75881 (UniProt - Evidence at protein level)

neXtProt

NX_O75881

Antibodypedia

CYP7B1 antibodies
 

PROTEIN VIEW

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CYP7B1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP7B1-001 ENSP00000310721
ENST00000310193
O75881
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