KAT5 - Gene info - The Human Protein Atlas

Gene name

KAT5 (HGNC Symbol)

Synonyms

cPLA2, ESA1, HTATIP, HTATIP1, PLIP, TIP60, ZC2HC5

Description

K(lysine) acetyltransferase 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q13.1

Chromosome location (bp)

65711996 - 65719604

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000172977 (version 78.38)

Entrez gene

10524

UniProt

Q92993 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KAT5-001

ENSP00000340330
ENST00000341318

Q92993
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Q92993 [Direct mapping]
Histone acetyltransferase KAT5
E9PJI1 [Target identity:55%; Query identity:100%]
Histone acetyltransferase KAT5 {ECO:0000313|Ensembl:ENSP00000431819}
E9PMG8 [Target identity:8%; Query identity:100%]
Histone acetyltransferase KAT5 {ECO:0000313|Ensembl:ENSP00000434993}

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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0000812 [Swr1 complex]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0006302 [double-strand break repair]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0008134 [transcription factor binding]
GO:0010212 [response to ionizing radiation]
GO:0016032 [viral process]
GO:0016573 [histone acetylation]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0030521 [androgen receptor signaling pathway]
GO:0032403 [protein complex binding]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032777 [Piccolo NuA4 histone acetyltransferase complex]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043234 [protein complex]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0050681 [androgen receptor binding]
GO:0070491 [repressing transcription factor binding]
GO:0071392 [cellular response to estradiol stimulus]

546

61.8

KAT5-002

ENSP00000366245
ENST00000377046

Q92993
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Q92993 [Direct mapping]
Histone acetyltransferase KAT5
A0A024R597 [Target identity:100%; Query identity:100%]
HIV-1 Tat interacting protein, 60kDa, isoform CRA_c {ECO:0000313|EMBL:EAW74432.1}
E9PJI1 [Target identity:58%; Query identity:100%]
Histone acetyltransferase KAT5 {ECO:0000313|Ensembl:ENSP00000431819}
E9PMG8 [Target identity:8%; Query identity:100%]
Histone acetyltransferase KAT5 {ECO:0000313|Ensembl:ENSP00000434993}

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000812 [Swr1 complex]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006302 [double-strand break repair]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0010212 [response to ionizing radiation]
GO:0016032 [viral process]
GO:0016573 [histone acetylation]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0030521 [androgen receptor signaling pathway]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032777 [Piccolo NuA4 histone acetyltransferase complex]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0050681 [androgen receptor binding]
GO:0070491 [repressing transcription factor binding]
GO:0071392 [cellular response to estradiol stimulus]

513

58.6

KAT5-003

ENSP00000344955
ENST00000352980

Q92993
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Q92993 [Direct mapping]
Histone acetyltransferase KAT5
A0A024R5E8 [Target identity:100%; Query identity:100%]
HIV-1 Tat interacting protein, 60kDa, isoform CRA_a {ECO:0000313|EMBL:EAW74428.1}
E9PJI1 [Target identity:65%; Query identity:100%]
Histone acetyltransferase KAT5 {ECO:0000313|Ensembl:ENSP00000431819}
E9PMG8 [Target identity:9%; Query identity:100%]
Histone acetyltransferase KAT5 {ECO:0000313|Ensembl:ENSP00000434993}

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461

53.1

KAT5-004

ENSP00000434765
ENST00000530446

Q92993
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Q92993 [Direct mapping]
Histone acetyltransferase KAT5
E9PJI1 [Target identity:61%; Query identity:100%]
Histone acetyltransferase KAT5 {ECO:0000313|Ensembl:ENSP00000431819}
E9PMG8 [Target identity:9%; Query identity:100%]
Histone acetyltransferase KAT5 {ECO:0000313|Ensembl:ENSP00000434993}

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494

56.3

KAT5-005

ENSP00000431819
ENST00000534650

E9PJI1
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E9PJI1 [Target identity:100%; Query identity:100%]
Histone acetyltransferase KAT5 {ECO:0000313|Ensembl:ENSP00000431819}
E9PMG8 [Target identity:14%; Query identity:100%]
Histone acetyltransferase KAT5 {ECO:0000313|Ensembl:ENSP00000434993}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]

302

35.4

KAT5-009

ENSP00000435766
ENST00000533596

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

10.9

KAT5-013

ENSP00000434993
ENST00000534681

E9PMG8
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E9PMG8 [Target identity:100%; Query identity:100%]
Histone acetyltransferase KAT5 {ECO:0000313|Ensembl:ENSP00000434993}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

5.3

KAT5-014

ENSP00000435939
ENST00000534104

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

1.7

KAT5-015

ENSP00000436000
ENST00000528198

E9PRM3
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E9PRM3 [Target identity:100%; Query identity:100%]
Histone acetyltransferase KAT5 {ECO:0000313|Ensembl:ENSP00000436000}

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Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

189

21.3

KAT5-016

ENSP00000436012
ENST00000531880

E9PRL6
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E9PRL6 [Target identity:100%; Query identity:100%]
Histone acetyltransferase KAT5 {ECO:0000313|Ensembl:ENSP00000436012}
E9PMG8 [Target identity:16%; Query identity:100%]
Histone acetyltransferase KAT5 {ECO:0000313|Ensembl:ENSP00000434993}

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Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005634 [nucleus]

269

KAT5-018

ENSP00000436247
ENST00000530605

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

167

18.5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.