KDM2A

GENE INFORMATION

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Gene name

KDM2A (HGNC Symbol)

Synonyms

CXXC8, DKFZP434M1735, FBL11, FBL7, FBXL11, FLJ00115, JHDM1A, KIAA1004, LILINA

Description

Lysine (K)-specific demethylase 2A (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Chromosome

11

Cytoband

q13.2

Chromosome location (bp)

67119269 - 67258087

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173120 (version 78.38)

Entrez gene

22992

UniProt

Q9Y2K7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y2K7

Antibodypedia

KDM2A antibodies
 

PROTEIN VIEW

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KDM2A-001
 
KDM2A-002
 
KDM2A-010
 
KDM2A-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KDM2A-001 ENSP00000381640
ENST00000398645
Q9Y2K7
Show all »
Show » Show » 782 89.9 No 0
KDM2A-002 ENSP00000432786
ENST00000529006
Q9Y2K7
Show all »
Show » Show » 1162 132.8 No 0
KDM2A-010 ENSP00000435776
ENST00000530342
Q9Y2K7
Show all »
Show » Show » 723 81.7 No 0
KDM2A-201 ENSP00000309302
ENST00000308783
I3VM54
Show all »
Show » Show » 1145 130.7 No 0