ESRRA - Gene info - The Human Protein Atlas

Gene name

ESRRA (HGNC Symbol)

Synonyms

ERR1, ERRa, ERRalpha, ESRL1, NR3B1

Description

Estrogen-related receptor alpha (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

Chromosome

Cytoband

q13.1

Chromosome location (bp)

64305572 - 64316743

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173153 (version 78.38)

Entrez gene

2101

UniProt

P11474 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ESRRA-001

ENSP00000385971
ENST00000406310

P11474
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P11474 [Direct mapping]
Steroid hormone receptor ERR1
F5GWT5 [Target identity:25%; Query identity:100%]
Steroid hormone receptor ERR1 {ECO:0000313|Ensembl:ENSP00000441970}
Q96F89 [Target identity:13%; Query identity:100%]
Putative uncharacterized protein {ECO:0000313|EMBL:AAH11528.1}

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Nuclear receptors
Predicted intracellular proteins
Transcription factors
Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)

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GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0019904 [protein domain specific binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045171 [intercellular bridge]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]

422

45.4

ESRRA-002

ENSP00000000442
ENST00000000442

P11474
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P11474 [Direct mapping]
Steroid hormone receptor ERR1
Q569H8 [Target identity:100%; Query identity:100%]
ESRRA protein {ECO:0000313|EMBL:AAH92470.1}; Estrogen-related nuclear receptor alpha {ECO:0000313|EMBL:ADZ17378.1}; Estrogen-related receptor alpha {ECO:0000313|EMBL:AAH63795.2}; HCG2016877, isoform CRA_b {ECO:0000313|EMBL:EAW74246.1}
Q96I02 [Target identity:75%; Query identity:100%]
ESRRA protein {ECO:0000313|EMBL:AAH07915.2}
F5H0E9 [Target identity:38%; Query identity:100%]
Steroid hormone receptor ERR1 {ECO:0000313|Ensembl:ENSP00000439896}
F5GWT5 [Target identity:25%; Query identity:100%]
Steroid hormone receptor ERR1 {ECO:0000313|Ensembl:ENSP00000441970}
Q96F89 [Target identity:13%; Query identity:100%]
Putative uncharacterized protein {ECO:0000313|EMBL:AAH11528.1}

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Nuclear receptors
Predicted intracellular proteins
Transcription factors
Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)

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423

45.5

ESRRA-003

ENSP00000384851
ENST00000405666

P11474
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Nuclear receptors
Predicted intracellular proteins
Transcription factors
Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0001078 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0019904 [protein domain specific binding]
GO:0030278 [regulation of ossification]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045171 [intercellular bridge]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045670 [regulation of osteoclast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051216 [cartilage development]

423

45.5

ESRRA-004

ENSP00000441970
ENST00000468670

F5GWT5
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F5GWT5 [Target identity:100%; Query identity:100%]
Steroid hormone receptor ERR1 {ECO:0000313|Ensembl:ENSP00000441970}

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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

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GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0015630 [microtubule cytoskeleton]
GO:0043565 [sequence-specific DNA binding]
GO:0045171 [intercellular bridge]

109

11.2

ESRRA-006

ENSP00000444710
ENST00000545035

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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

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GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043401 [steroid hormone mediated signaling pathway]

198

21.3

ESRRA-007

ENSP00000439896
ENST00000539594

F5H0E9
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F5H0E9 [Target identity:100%; Query identity:100%]
Steroid hormone receptor ERR1 {ECO:0000313|Ensembl:ENSP00000439896}

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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

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GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043401 [steroid hormone mediated signaling pathway]

162

17.4

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.