TNFRSF10C

GENE INFORMATION

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Gene name

TNFRSF10C (HGNC Symbol)

Synonyms

CD263, DcR1, LIT, TRAILR3, TRID

Description

Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

p21.3

Chromosome location (bp)

23084355 - 23117437

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173535 (version 78.38)

Entrez gene

8794

UniProt

O14798 (UniProt - Evidence at protein level)

neXtProt

NX_O14798

Antibodypedia

TNFRSF10C antibodies
 

PROTEIN VIEW

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TNFRSF10C-001
 
TNFRSF10C-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNFRSF10C-001 ENSP00000349324
ENST00000356864
O14798
Show all »
Show » Show » 259 27.4 Yes 1
TNFRSF10C-002 ENSP00000380815
ENST00000397703
E9PBT0
Show all »
Show » 155 16.2 No 0