LIG4 - Gene info - The Human Protein Atlas

Gene name

LIG4

Synonyms

Description

Ligase IV, DNA, ATP-dependent (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q33.3

Chromosome location (bp)

108207439 - 108218368

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000174405 (version 78.38)

Entrez gene

3981

UniProt

P49917 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LIG4-001

ENSP00000484288
ENST00000611712

P49917
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P49917 [Direct mapping]
DNA ligase 4
A0A024RE06 [Target identity:100%; Query identity:100%]
DNA ligase {ECO:0000256|RuleBase:RU000617}

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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000012 [single strand break repair]
GO:0000793 [condensed chromosome]
GO:0001701 [in utero embryonic development]
GO:0002328 [pro-B cell differentiation]
GO:0003677 [DNA binding]
GO:0003909 [DNA ligase activity]
GO:0003910 [DNA ligase (ATP) activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005958 [DNA-dependent protein kinase-DNA ligase 4 complex]
GO:0006266 [DNA ligation]
GO:0006273 [lagging strand elongation]
GO:0006281 [DNA repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0007049 [cell cycle]
GO:0007417 [central nervous system development]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0010165 [response to X-ray]
GO:0010212 [response to ionizing radiation]
GO:0010332 [response to gamma radiation]
GO:0016032 [viral process]
GO:0016874 [ligase activity]
GO:0032807 [DNA ligase IV complex]
GO:0033077 [T cell differentiation in thymus]
GO:0033151 [V(D)J recombination]
GO:0033152 [immunoglobulin V(D)J recombination]
GO:0033153 [T cell receptor V(D)J recombination]
GO:0035019 [somatic stem cell maintenance]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045190 [isotype switching]
GO:0046872 [metal ion binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050769 [positive regulation of neurogenesis]
GO:0051102 [DNA ligation involved in DNA recombination]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
GO:0051402 [neuron apoptotic process]
GO:0070419 [nonhomologous end joining complex]
GO:0071285 [cellular response to lithium ion]
GO:0071897 [DNA biosynthetic process]
GO:0075713 [establishment of integrated proviral latency]

911

104

LIG4-002

ENSP00000385955
ENST00000405925

P49917
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P49917 [Direct mapping]
DNA ligase 4
A0A024RE06 [Target identity:100%; Query identity:100%]
DNA ligase {ECO:0000256|RuleBase:RU000617}

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GO:0000012 [single strand break repair]
GO:0000793 [condensed chromosome]
GO:0001701 [in utero embryonic development]
GO:0002328 [pro-B cell differentiation]
GO:0003677 [DNA binding]
GO:0003909 [DNA ligase activity]
GO:0003910 [DNA ligase (ATP) activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005958 [DNA-dependent protein kinase-DNA ligase 4 complex]
GO:0006266 [DNA ligation]
GO:0006273 [lagging strand elongation]
GO:0006281 [DNA repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0007049 [cell cycle]
GO:0007417 [central nervous system development]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0016032 [viral process]
GO:0016874 [ligase activity]
GO:0032807 [DNA ligase IV complex]
GO:0033077 [T cell differentiation in thymus]
GO:0033151 [V(D)J recombination]
GO:0033153 [T cell receptor V(D)J recombination]
GO:0035019 [somatic stem cell maintenance]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045190 [isotype switching]
GO:0046872 [metal ion binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050769 [positive regulation of neurogenesis]
GO:0051102 [DNA ligation involved in DNA recombination]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
GO:0051402 [neuron apoptotic process]
GO:0070419 [nonhomologous end joining complex]
GO:0071897 [DNA biosynthetic process]
GO:0075713 [establishment of integrated proviral latency]

911

104

LIG4-003

ENSP00000402030
ENST00000442234

P49917
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P49917 [Direct mapping]
DNA ligase 4
A0A024RE06 [Target identity:100%; Query identity:100%]
DNA ligase {ECO:0000256|RuleBase:RU000617}

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GO:0000012 [single strand break repair]
GO:0000793 [condensed chromosome]
GO:0001701 [in utero embryonic development]
GO:0002328 [pro-B cell differentiation]
GO:0003677 [DNA binding]
GO:0003909 [DNA ligase activity]
GO:0003910 [DNA ligase (ATP) activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005958 [DNA-dependent protein kinase-DNA ligase 4 complex]
GO:0006266 [DNA ligation]
GO:0006273 [lagging strand elongation]
GO:0006281 [DNA repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0007049 [cell cycle]
GO:0007417 [central nervous system development]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0016032 [viral process]
GO:0016874 [ligase activity]
GO:0032807 [DNA ligase IV complex]
GO:0033077 [T cell differentiation in thymus]
GO:0033151 [V(D)J recombination]
GO:0033153 [T cell receptor V(D)J recombination]
GO:0035019 [somatic stem cell maintenance]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045190 [isotype switching]
GO:0046872 [metal ion binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050769 [positive regulation of neurogenesis]
GO:0051102 [DNA ligation involved in DNA recombination]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
GO:0051402 [neuron apoptotic process]
GO:0070419 [nonhomologous end joining complex]
GO:0071897 [DNA biosynthetic process]
GO:0075713 [establishment of integrated proviral latency]

911

104

LIG4-004

ENSP00000480814
ENST00000614526

P49917
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P49917 [Direct mapping]
DNA ligase 4

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GO:0000012 [single strand break repair]
GO:0000793 [condensed chromosome]
GO:0001701 [in utero embryonic development]
GO:0002328 [pro-B cell differentiation]
GO:0003677 [DNA binding]
GO:0003909 [DNA ligase activity]
GO:0003910 [DNA ligase (ATP) activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005958 [DNA-dependent protein kinase-DNA ligase 4 complex]
GO:0006266 [DNA ligation]
GO:0006273 [lagging strand elongation]
GO:0006281 [DNA repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0007049 [cell cycle]
GO:0007417 [central nervous system development]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0016032 [viral process]
GO:0016874 [ligase activity]
GO:0032807 [DNA ligase IV complex]
GO:0033077 [T cell differentiation in thymus]
GO:0033151 [V(D)J recombination]
GO:0033153 [T cell receptor V(D)J recombination]
GO:0035019 [somatic stem cell maintenance]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045190 [isotype switching]
GO:0046872 [metal ion binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050769 [positive regulation of neurogenesis]
GO:0051102 [DNA ligation involved in DNA recombination]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
GO:0051402 [neuron apoptotic process]
GO:0070419 [nonhomologous end joining complex]
GO:0071897 [DNA biosynthetic process]
GO:0075713 [establishment of integrated proviral latency]

844

96.2

LIG4-201

ENSP00000349393
ENST00000356922

P49917
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P49917 [Direct mapping]
DNA ligase 4
A0A024RE06 [Target identity:100%; Query identity:100%]
DNA ligase {ECO:0000256|RuleBase:RU000617}

Show » « Hide

GO:0000012 [single strand break repair]
GO:0000793 [condensed chromosome]
GO:0001701 [in utero embryonic development]
GO:0002328 [pro-B cell differentiation]
GO:0003677 [DNA binding]
GO:0003909 [DNA ligase activity]
GO:0003910 [DNA ligase (ATP) activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005958 [DNA-dependent protein kinase-DNA ligase 4 complex]
GO:0006266 [DNA ligation]
GO:0006273 [lagging strand elongation]
GO:0006281 [DNA repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0007049 [cell cycle]
GO:0007417 [central nervous system development]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0016032 [viral process]
GO:0016874 [ligase activity]
GO:0032807 [DNA ligase IV complex]
GO:0033077 [T cell differentiation in thymus]
GO:0033151 [V(D)J recombination]
GO:0033153 [T cell receptor V(D)J recombination]
GO:0035019 [somatic stem cell maintenance]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045190 [isotype switching]
GO:0046872 [metal ion binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050769 [positive regulation of neurogenesis]
GO:0051102 [DNA ligation involved in DNA recombination]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
GO:0051402 [neuron apoptotic process]
GO:0070419 [nonhomologous end joining complex]
GO:0071897 [DNA biosynthetic process]
GO:0075713 [establishment of integrated proviral latency]

911

104

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.