NLRP6

GENE INFORMATION

? »

Gene name

NLRP6 (HGNC Symbol)

Synonyms

CLR11.4, NALP6, PAN3, PYPAF5

Description

NLR family, pyrin domain containing 6 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Chromosome

11

Cytoband

p15.5

Chromosome location (bp)

278365 - 285359

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000174885 (version 78.38)

Entrez gene

171389

UniProt

P59044 (UniProt - Evidence at transcript level)

neXtProt

NX_P59044

Antibodypedia

NLRP6 antibodies
 

PROTEIN VIEW

? »
 
 
 
NLRP6-001
 
NLRP6-002
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NLRP6-001 ENSP00000309767
ENST00000312165
P59044
Show all »
Show » Show » 892 98.8 No 0
NLRP6-002 ENSP00000433617
ENST00000534750
P59044
Show all »
Show » Show » 891 98.7 No 0