PCCA

GENE INFORMATION

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Gene name

PCCA

Synonyms

Description

Propionyl CoA carboxylase, alpha polypeptide (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

Chromosome

13

Cytoband

q32.3

Chromosome location (bp)

100089015 - 100530435

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175198 (version 78.38)

Entrez gene

5095

UniProt

P05165 (UniProt - Evidence at protein level)

neXtProt

NX_P05165

Antibodypedia

PCCA antibodies
 

PROTEIN VIEW

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PCCA-001
 
PCCA-002
 
PCCA-003
 
PCCA-004
 
PCCA-005
 
PCCA-007
 
PCCA-201
 
PCCA-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PCCA-001 ENSP00000365462
ENST00000376285
P05165
Show all »
Show » Show » 728 80.1 No 0
PCCA-002 ENSP00000400740
ENST00000443601
Show » Show » 139 15.6 No 0
PCCA-003 ENSP00000396050
ENST00000424527
Q5JTW6
Show all »
Show » 149 16.5 No 0
PCCA-004 ENSP00000390850
ENST00000458283
Show » 134 14.1 No 0
PCCA-005 ENSP00000411194
ENST00000413170
Show » Show » 84 9 No 0
PCCA-007 ENSP00000399413
ENST00000428969
Q5JVH2
Show all »
Show » 111 11.9 No 0
PCCA-201 ENSP00000365456
ENST00000376279
P05165
Show all »
Show » Show » 681 75 No 0
PCCA-202 ENSP00000365463
ENST00000376286
P05165
Show all »
Show » Show » 702 77 No 0