NR2C2

GENE INFORMATION

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Gene name

NR2C2 (HGNC Symbol)

Synonyms

hTAK1, TAK1, TR2R1, TR4

Description

Nuclear receptor subfamily 2, group C, member 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Chromosome

3

Cytoband

p25.1

Chromosome location (bp)

14947584 - 15053600

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000177463 (version 78.38)

Entrez gene

7182

UniProt

P49116 (UniProt - Evidence at protein level)

neXtProt

NX_P49116

Antibodypedia

NR2C2 antibodies
 

PROTEIN VIEW

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NR2C2-001
 
NR2C2-002
 
NR2C2-004
 
NR2C2-006
 
NR2C2-008
 
NR2C2-009
 
NR2C2-011
 
NR2C2-012
 
NR2C2-201
 
NR2C2-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NR2C2-001 ENSP00000320447
ENST00000323373
P49116
Show all »
Show » Show » 615 67.3 No 0
NR2C2-002 ENSP00000388387
ENST00000425241
P49116
Show all »
Show » Show » 596 65.4 No 0
NR2C2-004 ENSP00000376814
ENST00000393102
P49116
Show all »
Show » Show » 596 65.4 No 0
NR2C2-006 ENSP00000402272
ENST00000413118
C9JMI6
Show all »
Show » 67 6.9 No 0
NR2C2-008 ENSP00000391473
ENST00000435454
C9J2Y1
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Show » 36 3.7 No 0
NR2C2-009 ENSP00000401807
ENST00000437120
C9JKS0
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Show » Show » 205 22.3 No 0
NR2C2-011 ENSP00000412473
ENST00000439011
H7C3L1
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Show » Show » 222 25.2 No 0
NR2C2-012 ENSP00000413438
ENST00000413194
H7C3R1
Show all »
Show » Show » 173 19.8 No 0
NR2C2-201 ENSP00000384463
ENST00000406272
P49116
Show all »
Show » Show » 596 65.4 No 0
NR2C2-202 ENSP00000483059
ENST00000617312
P49116
Show all »
Show » Show » 615 67.3 No 0