PIDD1

GENE INFORMATION

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Gene name

PIDD1 (HGNC Symbol)

Synonyms

DKFZp434D229, LRDD, MGC16925, PIDD

Description

P53-induced death domain protein 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

Chromosome

11

Cytoband

p15.5

Chromosome location (bp)

799179 - 809753

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000177595 (version 78.38)

Entrez gene

55367

UniProt

Q9HB75 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HB75

Antibodypedia

PIDD1 antibodies
 

PROTEIN VIEW

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PIDD1-001
 
PIDD1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PIDD1-001 ENSP00000337797
ENST00000347755
Q9HB75
Show all »
Show » Show » 910 99.7 No 0
PIDD1-002 ENSP00000416801
ENST00000411829
Q9HB75
Show all »
Show » Show » 893 97.8 No 0