RPLP2

GENE INFORMATION

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Gene name

RPLP2 (HGNC Symbol)

Synonyms

D11S2243E, LP2, MGC71408, P2, RPP2

Description

Ribosomal protein, large, P2 (HGNC Symbol)

Entrez gene summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.5

Chromosome location (bp)

809647 - 812880

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000177600 (version 78.38)

Entrez gene

6181

UniProt

P05387 (UniProt - Evidence at protein level)

neXtProt

NX_P05387

Antibodypedia

RPLP2 antibodies
 

PROTEIN VIEW

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RPLP2-001
 
RPLP2-002
 
RPLP2-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RPLP2-001 ENSP00000322419
ENST00000321153
P05387
Show all »
Show » Show » 115 11.7 Yes 0
RPLP2-002 ENSP00000431240
ENST00000530797
P05387
Show all »
Show » Show » 115 11.7 Yes 0
RPLP2-009 ENSP00000433443
ENST00000530398
Show » Show » 92 9 No 0